|
KMID : 0043319860090040219
|
|
Archives of Pharmacal Research
1986 Volume.9 No. 4 p.219 ~ p.222
|
|
|
Effect of Alpha-2 Adrenergic Agonist on Beta Adrenoceptor-Mediated Control of Blood Glucose in the Fasted Mouse
|
|
Hang GI
Kim MY
|
|
|
Abstract
|
|
|
|
Dose-dependent increases in blood glucose were produced by epinephrine and clonidine in fasted male mice. Isoproterenol was ineffective in increasing blood glucose at lower doses (10-7M/kg-10-7M/kg); with higher dose (10-6M/kg) the glucose level was increased. The hyperglycemia induced by epinephrine was inhibited by yohimbine, prazosin and propranolol, indicating that the hyperglycemic effect of epinephrine is mediated by alpha-1, alpha-2 and beta adrenoceptor. When clonidine (10-6M/kg) was administered simultaneously with isoproterenol (10-6M/kg), an enhenced hyperglycemic effect was observed. The increment produced by clonidine plus isoproterenol was higher than that by clonidine alone. These results suggest that stimulation of alpha-2 adrenoceptor may be responsible for the exertion of the hyperglycemic effect by beta agonists in fasted mice.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|